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KMID : 0364219810240020059
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Korean Journal of Zoology
1981 Volume.24 No. 2 p.59 ~ p.64
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Cytocidal Effect of Hyperthermia on Tumor Cells in vivo
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Kang Man-Sik
Rhee Jeong-Gile
Levitt Seymour H.
Song Chang-W.
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Abstract
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The cytocidal effect of hyperthermia on subcutaneous SCK tumor cells growing in vivo was significantly greater than that on the SCK tumor cells cultured in vitro. When the tumors were left in situ after heating, the cell survival progressively decreased, and the functional intratumor vascular volume also decreased. The radiation survival curves of tumor cells heated either 30 min before or after X-irradiation in vivo were steeper than the radiation survival curves of unheated control tumors. It is concluded that the cytocidal effect of hyperthermia on tumor cells in vivo is greater than that in vitro due possibly to the intratumor environment.
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